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B6.129(Cg)-Scn10atm2(cre)Jwo/TjpJ
Cat. No.: CEMM-07251063
Common Name: Nav1.8-Cre
Nav1.8-Cre knock-in/knock-out mice carry Cre recombinase under the control of the Scn10a (sodium channel, voltage-gated, type X, alpha or Nav1.8) promoter. Cre expression is observed beginning at E14 in small diameter neurons in dorsal root, trigeminal and nodose ganglia. Mice heterozygous for the mutation can be used as a tool in pain behavior studies to delete floxed genes only in nociceptors.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Scn10atm2(cre)Jwo
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Scn10a
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| Gene Name |
sodium channel
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| Chromosome |
9
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
Cre recombinase, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. Cre expression was observed beginning at embryonic day 14 in small-diameter neurons in dorsal root, trigeminal, and nodose ganglia but absent in nonneuronal and CNS tissues.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice are bred by heterozygote or homozygote sibling matings. For use as a tool for cre recombinase expression, mice should be maintained as heterozygotes.
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| Breeding Strategy |
Heterozygote x Homozygote; Homozygote x Heterozygote
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For Research Use Only.
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