Online Inquiry
Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129-Kalrntm2Npl/J (Cat. No.: CEMM-07250869) | Inquiry | |
|
KalSRCKO mice possess loxP sites flanking exon 13 of the kalirin, RhoGEF kinase (Kalrn) gene. These mice are useful when studying the role of Kalirin in cardiovascular disease, psychiatric disorders and neurodegeneration.
show more
close
|
||
| B6NJ;129S-Pou6f1tm1.1Arenk/J (Cat. No.: CEMM-07250899) | Inquiry | |
|
POU6f1floxed Exon2-11 mice possess loxP sites flanking exons 2-11 of the POU domain, class 6, transcription factor 1 gene. These floxed mice are useful for tissue specific deletion of Pou6f1 when studying neuronal plasticity in the adult brain.
show more
close
|
||
| B6.Cg-Shank3tm2Bux/J (Cat. No.: CEMM-07250905) | Inquiry | |
|
Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from cryorecovery.Shank3flox ex4-22 mice possess loxP sites flanking exons 4-22 of the SH3 and multiple ankyrin repeat domains 3 (Shank3) gene. These mice are suitable for use in making complete tissue-specific Shank3 knock-out mice and may be useful for studying autism spectrum disorder (ASD), Phelan-McDermid syndrome and schizophrenia.
show more
close
|
||
| B6(SJL)-Prdm16tm1.1Snok/J (Cat. No.: CEMM-07250906) | Inquiry | |
|
Prdm16fl/fl mice possess loxP sites flanking exons 6-7 of the PR domain containing 16 (Prdm16) gene. These floxed mice are useful for tissue specific deletion of Prdm16 when studying hematopoiesis and inflammatory gene expression in leukemia.
show more
close
|
||
| B6;129S-Trhtm1.1(cre)Mjkr/LowlJ (Cat. No.: CEMM-07250919) | Inquiry | |
|
Trh-ires-Cre knock-in mice express Cre recombinase under direction of the thyrotropin releasing hormone promoter in the paraventricular hypothalamus making them useful for cell-specific neuron mapping. Unlike conventional cre-expressing mice, the donating investigator reports that the early embryonic expression of Trh, and thus the early embryonic expression of Cre, results in deletion of the floxed sequences in all cells of adult mice. However, these mice are very useful when used in conjunction with injection of Cre-dependent AAVs into brains of adult Trh-ires-Cre mice.
show more
close
|
||
| B6(129S4)-Serpine1tm1c(EUCOMM)Hmgu/RliuJ (Cat. No.: CEMM-07250921) | Inquiry | |
|
PAI-1flox mice have exons 4-5 of the Serpine1 gene floxed, making these mice useful for studying mechanisms underlying the pathophysiology of diseases including cardiovascular diseases, thrombosis, cancers, fibrosis, asthma, and Alzheimer's disease, as well as aging.
show more
close
|
||
| B6.Cg-Ckap5tm1.1Eba/J (Cat. No.: CEMM-07250922) | Inquiry | |
|
Floxed TOG mice possess loxP sites flanking exons 4-6 of the cytoskeleton associated protein 5 (Ckap5) gene. These floxed mice are useful when studying the role of TOG in microtubule dynamics regulation and myelination.
show more
close
|
||
| STOCK Lgi1tm2.1Jkc/J (Cat. No.: CEMM-07250938) | Inquiry | |
|
LGI1flox mice possess loxP sites flanking exons 3-4 of the leucine-rich repeat LGI family, member 1 (Lgi1) gene. These floxed mice are useful when studying the pathogenesis of LGI1-related epilepsies.
show more
close
|
||
| B6;129S-Grptm2Zfc/J (Cat. No.: CEMM-07250942) | Inquiry | |
|
GrpF mice possess loxP sites flanking exon 1 of the gastrin releasing peptide (Grp) gene. These floxed mice are useful when studying non-histaminergic scratching behavior.This contains a frt-flanked neo cassette within the floxed region. It is unknown if this affects expression of the endogenous protein. As such, this strain was bred to a Flpo recombinase expressing mouse line, to remove the neo cassette. This new strain, lacking neo, is available as.
show more
close
|
||
| B6.129S7(FVB)-Rtn4tm1.1Bzh/J (Cat. No.: CEMM-07250949) | Inquiry | |
|
Nogof have loxP sites flanking the two exons that are common to the three major reticulon 4 (Rtn4) isoforms (Nogo-A,B,C). These mice are useful when studying axon sprouting and repair as well as other forms of neural plasticity and myelination after central nervous system injury.
show more
close
|
||
For Research Use Only.