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B6(129S4)-Serpine1tm1c(EUCOMM)Hmgu/RliuJ
Cat. No.: CEMM-07250921
Common Name: PAI-1flox
PAI-1flox mice have exons 4-5 of the Serpine1 gene floxed, making these mice useful for studying mechanisms underlying the pathophysiology of diseases including cardiovascular diseases, thrombosis, cancers, fibrosis, asthma, and Alzheimer's disease, as well as aging.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Serpine1tm1c(EUCOMM)Hmgu
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| Allele Name |
targeted mutation 1c
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Serpine1
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| Gene Name |
serine (or cysteine) peptidase inhibitor
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| Chromosome |
5
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
The L1L2_Bact_P cassette was inserted at a position on Chromosome 5 upstream of exon 4 of the gene. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the FRT flanked beta-gal/neomycin resistance cassette leaving exons 4 and 5 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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