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STOCK Lgi1tm2.1Jkc/J
Cat. No.: CEMM-07250938
Common Name: LGI1flox
LGI1flox mice possess loxP sites flanking exons 3-4 of the leucine-rich repeat LGI family, member 1 (Lgi1) gene. These floxed mice are useful when studying the pathogenesis of LGI1-related epilepsies.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Lgi1tm2.1Jkc
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Lgi1
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| Gene Name |
leucine-rich repeat LGI family
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| Chromosome |
19
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
The targeting vector is designed to insert a loxP site upstream of exon 3, and an FRT flanked neomycin selection cassette followed by a second loxP site downstream of exon 4. Flp-mediated recombination removed the FRT flanked neo cassette leaving exons 3 thorugh 4 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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