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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129-Kcnj10tm1Kdmc/J (Cat. No.: CEMM-07250611) | Inquiry | |
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Kir4.1f/f floxed mice may be useful for studying astrocyte potassium buffering.
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| D2.Cg-Tg(Thy1-Brainbow1.0)LLich/SjJ (Cat. No.: CEMM-07250613) | Inquiry | |
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These Brainbow transgenic mice allow labeling of individual neuronal types with approximately 166 distinguishable color variations in cre recombined cells, and may also be useful in conjunction with other Brainbow strains for neurobiological studies.
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| B6.Cg-Gt(ROSA)26Sortm1.1(CAG-tdTomato, -EGFP)Pjen/J (Cat. No.: CEMM-07250619) | Inquiry | |
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The RC::RFLTG triple-recombinase responsive indicator allele is designed with a rox-flanked STOP, frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Dre- and FLP-recombinase result in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::RFLTG allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of three gene expression domains.
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| B6.Cg-Gt(ROSA)26Sortm1.2(CAG-tdTomato, -EGFP)Pjen/J (Cat. No.: CEMM-07250620) | Inquiry | |
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RC::RLTG dual-recombinase responsive indicator is designed with a rox-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Dre recombinase results in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::RLTG allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of two gene expression domains.
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| B6.Cg-Gt(ROSA)26Sortm1.3(CAG-tdTomato, -EGFP)Pjen/J (Cat. No.: CEMM-07250621) | Inquiry | |
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The RC::FLTG dual-recombinase responsive indicator allele is designed with a frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Flp recombinase results in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::FLTG allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of two gene expression domains.
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| B6;129S-Serpina3ntm1.1Lbrl/J (Cat. No.: CEMM-07250637) | Inquiry | |
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Serpina3nfl/fl floxed mice may be useful for developing therapeutic approaches to relieve receptor-activated neuropathic pain.
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| B6.129(SJL)-Scn4btm1.1Geh/RahJ (Cat. No.: CEMM-07250638) | Inquiry | |
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Scn4b floxed mice may be useful for studying the role of sodium channel beta subunits on the gating properties of sodium channels.
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| B6J.B6NTac(C3)-Kcnmb2tm1.1Clin/J (Cat. No.: CEMM-07250666) | Inquiry | |
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BK β2 floxed mice possess loxP sites flanking exon 1 of the Kcnmb2 gene, making this strain useful for studying the regulation of BK channel activation.
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| B6(129S4)-Kcnt2tm1.1Clin/J (Cat. No.: CEMM-07250667) | Inquiry | |
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Slick floxed mice possess loxP sites flanking exon 22 of the Kcnt2 gene, making this strain useful for studying the regulation of neuronal excitability mutations in Slick channels.
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| B6;129S4-Pvalbtm2(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250676) | Inquiry | |
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PV-2A-CreER knock-in mice express the CreERT2 fusion protein in parvalbumin positive neurons of the neocortex and cerebellum, as directed by the endogenous Pvalb promoter/enhancer elements.
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For Research Use Only.