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B6(129S4)-Kcnt2tm1.1Clin/J
Cat. No.: CEMM-07250667
Common Name: Slick floxed
Slick floxed mice possess loxP sites flanking exon 22 of the Kcnt2 gene, making this strain useful for studying the regulation of neuronal excitability mutations in Slick channels.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kcnt2tm1.1Clin
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Kcnt2
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| Gene Name |
potassium channel
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
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| Molecular Note |
A targeting vector was designed to insert a loxP site upstream of exon 22 and a second loxP site downstream of exon22, followed by an FRT flanked neomycin resistance (neo) cassette which includes a third loxP site. FLP-mediated recombination removed the FRT flanked neo cassette leaving exon 22 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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