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B6;129S4-Pvalbtm2(cre/ERT2)Zjh/J
Cat. No.: CEMM-07250676
Common Name: PV-2A-CreER
PV-2A-CreER knock-in mice express the CreERT2 fusion protein in parvalbumin positive neurons of the neocortex and cerebellum, as directed by the endogenous Pvalb promoter/enhancer elements.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pvalbtm2(cre/ERT2)Zjh
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Pvalb
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| Gene Name |
parvalbumin
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| Chromosome |
15
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
Driven by Pvalb promoter/enhancer elements following induction by Tamoxifen, cre/ERT2 fusion protein is expressed in parvalbumin positive neurons in neocortex and cerebellum of the offspring.
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| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
A targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), followed by a FRT flanked neo cassette, upstream of the stop codon.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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