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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S4-Ror1tm1.1Meg/J (Cat. No.: CEMM-07250396) | Inquiry | |
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These Ror1f/f conditional mutant mice may have applications in studies related to Wnt5a-mediated signaling during embryonic development.
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| B6;129S4-Ror2tm1.1Meg/J (Cat. No.: CEMM-07250397) | Inquiry | |
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These Ror1f/f conditional mutant mice may have applications in studies related to Wnt5a-mediated signaling during embryonic development.
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| B6N.129S1(Cg)-Lrrc7tm1.2Mabk/J (Cat. No.: CEMM-07250401) | Inquiry | |
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Densinflox mice possess loxP sites flanking exon 3, a region encoding the transcriptional start site of the leucine rich repeat containing 7 (Lrrc7) gene, and may be useful in studying behavioral and synaptic defects associated with schizophrenia and autism spectrum disorder.
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| B6N.129-Gria1tm2Rsp/J (Cat. No.: CEMM-07250414) | Inquiry | |
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The GluA1fl floxed exon 11 allele allows deletion of the sequences encoding the glutamate receptor transmembrane domain ion channel pore in cells/tissues expressing Cre recombinase. These mice are useful in applications related to the study of behavioral, social and cognitive abnormalities, hippocampal synaptic transmission/plasticity, nociception and short and long term memory, as well as neuropsychiatric disorders such as schizophrenia and depression/mania.
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| B6.129S6(Cg)-Kcnn3tm2.1Jpad/J (Cat. No.: CEMM-07250418) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the exon1/intron1 region of the Kcnn3 gene and have applications in studies related to studying action potentials in SK3-expressing dopaminergic neurons.
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| B6.129-Mapk1tm1Gela/J (Cat. No.: CEMM-07250421) | Inquiry | |
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Mapk1flox (Erk2fl) mice may be useful for conditional deletion of MAPK1 in tissues involved in development.
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| B6;129S-Sptbn1tm1.1Mnr/J (Cat. No.: CEMM-07250426) | Inquiry | |
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These mice possess loxP sites flanking exon 3 of βII-spectrin. This strain may be useful for studying distal axon-cytoskeleton interactions and functions.
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| STOCK Gabrg2tm1Wul/J (Cat. No.: CEMM-07250439) | Inquiry | |
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These γ2I77lox mice contain the point mutation F77I and contain loxP sites flanking exon 4 of the gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 (Gabrg2) gene. GABAA receptors are rendered zolpidem-insensitive and allow cell type-specific ablations of the GABAA receptor γ2 subunit.
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| STOCK Igs5tm2.1(ACTB-EGFP, -tdTomato)Luo/J (Cat. No.: CEMM-07250450) | Inquiry | |
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The MADM-7GT (Igs5GT) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of mut4-EGFP, a beta-globin intronic sequence (containing frt and lox sites), and the MYC-tagged C-terminal portion of tdTomato all inserted into the Igs5 locus on chromosome 7 (~2.13 cM; ~0.7 kbp downstream of exon 5 of the Rps9 gene). These MADM-7GT mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-7TG mice harboring a reciprocal mutation at the same locus. This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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| STOCK Igs6tm2.1(ACTB-EFGP, -tdTomato)Luo/J (Cat. No.: CEMM-07250452) | Inquiry | |
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The MADM-12GT (Igs6GT) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of mut4-EGFP, a beta-globin intronic sequence (containing an frt site and loxP site), and the MYC-tagged C-terminal portion of tdTomato all inserted into the Igs6 locus on chromosome 12 (~1.71 cM; ~16 kbp downstream of exon 1 of the Rab10 gene). These MADM-12GT mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-12TG mice harboring a reciprocal mutation at the same locus. This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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For Research Use Only.