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B6.129S6(Cg)-Kcnn3tm2.1Jpad/J
Cat. No.: CEMM-07250418
Common Name: KCNN3 floxed; SK3flox
These floxed mutant mice possess loxP sites flanking the exon1/intron1 region of the Kcnn3 gene and have applications in studies related to studying action potentials in SK3-expressing dopaminergic neurons.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kcnn3tm2.1Jpad
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Kcnn3
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| Gene Name |
potassium intermediate/small conductance calcium-activated channel
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A targeting vector was designed to insert a loxP site upstream of the translation initiation codon in exon 1. A FRT flanked neomycin resistance (neo) cassette and a second loxP site were inserted downstream of exon 1. Heterozygous mice were bred with Flp transgenic mice to delete the neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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