Online Inquiry
B6N.129-Gria1tm2Rsp/J
Cat. No.: CEMM-07250414
Common Name: GluR-A2lox
The GluA1fl floxed exon 11 allele allows deletion of the sequences encoding the glutamate receptor transmembrane domain ion channel pore in cells/tissues expressing Cre recombinase. These mice are useful in applications related to the study of behavioral, social and cognitive abnormalities, hippocampal synaptic transmission/plasticity, nociception and short and long term memory, as well as neuropsychiatric disorders such as schizophrenia and depression/mania.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gria1tm2Rsp
show more
close
|
| Allele Name |
targeted mutation 2
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
show more
close
|
| Gene Symbol |
Gria1
show more
close
|
| Gene Name |
glutamate receptor
show more
close
|
| Chromosome |
11
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
show more
close
|
| Molecular Note |
A floxed neo cassette was inserted 700 bp into exon 11 along with an additional loxP site inserted upstream of exon 10. This allele was used to generate Gria1tm1Rsp by transfecting targeted ES cells with a Cre-expressing vector (pMC-Cre).
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
show more
close
|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
show more
close
|
For Research Use Only.
Related Products