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STOCK Gabrg2tm1Wul/J

Cat. No.: CEMM-07250439

These γ2I77lox mice contain the point mutation F77I and contain loxP sites flanking exon 4 of the gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 (Gabrg2) gene. GABAA receptors are rendered zolpidem-insensitive and allow cell type-specific ablations of the GABAA receptor γ2 subunit.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Gabrg2tm1Wul
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Gabrg2
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Gene Name
gamma-aminobutyric acid (GABA) A receptor
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Chromosome
11
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MGI Accession ID
3721943
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Strain of Origin
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Molecular Note
Exon 4 was replaced with an exon containing a phenylalanine to isoleucine mutation at position 77 (F77I). This point mutation confers drug insensitivity to zolpidem. A loxP site was inserted in the upstream intron and a FRT flanked neomycin cassette followed by another loxP site was inserted in the downstream intron. Chimeric mice were mated with a Flp deleter strain to remove the neomycin cassette. Genomic sequencing of homozygous mice confirmed the presence of the F to I mutation.
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HUSBANDRY
Breeding Considerations
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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