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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Pomt2tm1.1Hhu/J (Cat. No.: CEMM-07250368) | Inquiry | |
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These floxed-POMT2 mice may be useful for studying central nervous system malformations such as Walker-Warburg syndrome and muscle-eye-brain disease.
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| B6.Cg-Shank3tm1.1Bux/J (Cat. No.: CEMM-07250369) | Inquiry | |
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Shank3flox ex4-9 mice possess loxP sites flanking the ankyrin repeat domains (exons 4-9) of the Shank3 gene. These mice are suitable for use in making tissue-specific conditional mutations when used in conjunction with a Cre-expressing strain.
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| STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*, -tTA2)Luo/J (Cat. No.: CEMM-07250373) | Inquiry | |
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The R26G-tTA2 allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM G-tTA2" (GFPN-terminus-intron-tTA2ATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. These mutant mice are designed to combine the "new MADM-6" system with a Tet-Off binary expression system to create MADM-Tet (mosaic analysis with double markers combined with Tet-Off). This is a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling/tTA2-expression in daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice are also a Tet-Off tool enabling a TRE transgene to be conditionally expressed in a subset of MADM-labeled cells.
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| STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J (Cat. No.: CEMM-07250379) | Inquiry | |
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The R26TG allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM TG" cassette (ATG-intron-GFPC-terminus) inserted into the Gt(ROSA)26Sor locus on chromosome 6. The new TG cassette in R26TG mice is compatible with any "GX cassette" (GFPN-terminus-intron-XATG-less) where XATG-less is any gene without the start codon. Like the original MADM system, the "new MADM-6" system provides a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis, as well as for the MADM-Tet system.
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| STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J (Cat. No.: CEMM-07250380) | Inquiry | |
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The R26TT allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM TT" cassette inserted into the Gt(ROSA)26Sor locus on chromosome 6. These R26TT mice exhibit widespread expression of tdTomato-3Myc (tdT3Myc) and represent the tdTomato-expressing control strain for "new MADM-6" (new mosaic analysis with double markers on chromosome 6) experiments.
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| STOCK Igs3tm2.1(ACTB-EGFP*, -tdTomato)Luo/J (Cat. No.: CEMM-07250381) | Inquiry | |
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The Miya10GT (M10GT) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM GT" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
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| STOCK Igs3tm1.1(ACTB-EGFP*)Luo/J (Cat. No.: CEMM-07250385) | Inquiry | |
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The Miya10TG (M10TG) transgene has the CMV enhancer/chicken beta-actin core promoter upstream of a frt-flanked "MADM TG" cassette, all inserted into an intergenic region on chromosome 10 (~21 Mbp; between the Ahi1 and Myb loci). These mutant mice are designed for MADM-10 (mosaic analysis with double markers on chromosome 10), and provide a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
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| B6.129-Ulk1tm1Thsn/J (Cat. No.: CEMM-07250388) | Inquiry | |
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These floxed Ulk1FL mice may be useful for studying the mechanisms of autophagy.
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| B6;129-Pitx2tm1.1Sac/J (Cat. No.: CEMM-07250389) | Inquiry | |
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These Pitx2flox mice are useful when studying heart, eye, and pituitary gland development.
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| B6.129(Cg)-Itm2btm1Ldad/J (Cat. No.: CEMM-07250390) | Inquiry | |
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These BRI2f/f mice possess loxP sites flanking exon 2 of the Itm2b gene and may have applications in studies related to dementia and Alzheimer's Disease.
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For Research Use Only.