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B6.Cg-Shank3tm1.1Bux/J
Cat. No.: CEMM-07250369
Common Name: Shank3flox ex4-9
Shank3flox ex4-9 mice possess loxP sites flanking the ankyrin repeat domains (exons 4-9) of the Shank3 gene. These mice are suitable for use in making tissue-specific conditional mutations when used in conjunction with a Cre-expressing strain.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Shank3tm1.1Bux
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Shank3
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| Gene Name |
SH3 and multiple ankyrin repeat domains 3
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
B6.Cg-Thy1a
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| Molecular Note |
A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 9 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 4 - 9. Quantitative PCR and immunoblot analysis confirmed the absence of mRNA and protein expression in homozygous mice.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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