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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Tg(mI56i-cre, EGFP)1Kc/J (Cat. No.: CEMM-07250514) | Inquiry | |
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These Dlx5/6-Cre-IRES-EGFP transgenic mice may be useful for generating specific deletions of floxed alleles in ventral forebrain neuronal populations with fluorescent expression.
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| B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J (Cat. No.: CEMM-07250052) | Inquiry | |
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These ZW mice harbor a Cre-conditional pCZW transgene and have widespread expression of lacZ under the control of the CMV enhancer/chicken actin promoter. When bred to mice expressing Cre recombinase, the "floxed" lacZ sequence is removed in the resulting offspring, and lacZ expression is replaced by wheat germ agglutinin (plant lectin) expression in all cre-expressing cells. These ZW mice may be useful for global expression of lacZ or, when crossed to a cre-expressing strain, for tracing transneuronal or trans-synaptic connections and circuits in brain regions or in the spinal cord.
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| B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J (Cat. No.: CEMM-07250050) | Inquiry | |
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When these Sim1-Cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequences in Sim1-expressing tissues (including hypothalamus). As such, Sim1-Cre transgenic mice may be useful in studying body weight homeostasis, obesity, leptin metabolism, or as a reporter strain for Sim1-transcription factor activity.
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| B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J (Cat. No.: CEMM-07250051) | Inquiry | |
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These ZW mice harbor a Cre-conditional pCZW transgene and have widespread expression of lacZ under the control of the CMV enhancer/chicken actin promoter. When bred to mice expressing Cre recombinase, the "floxed" lacZ sequence is removed in the resulting offspring, and lacZ expression is replaced by wheat germ agglutinin (plant lectin) expression in all cre-expressing cells. These ZW mice may be useful for global expression of lacZ or, when crossed to a cre-expressing strain, for tracing transneuronal or trans-synaptic connections and circuits in brain regions or in the spinal cord.
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| STOCK Tg(Sim1-cre)1Lowl/J (Cat. No.: CEMM-07250049) | Inquiry | |
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When these Sim1-Cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequences in Sim1-expressing tissues (including hypothalamus). As such, Sim1-Cre transgenic mice may be useful in studying body weight homeostasis, obesity, leptin metabolism, or as a reporter strain for Sim1-transcription factor activity.
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| STOCK Tg(Thy1-Brainbow3.1)3Jrs/J (Cat. No.: CEMM-07250442) | Inquiry | |
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These Brainbow 3.1 (founder line 3) mice allow labeling of individual neuronal types (including motor neurons, cortical neurons, hippocampal neurons, cerebellar neurons, and cerebellar Purkinje cells) with up to 90 distinguishable color variations in cre recombined cells.
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| STOCK Tg(Thy1-Brainbow3.1)18Jrs/J (Cat. No.: CEMM-07250443) | Inquiry | |
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These Brainbow 3.1 (founder line 18) mice allow labeling of individual neuronal types (including neurons in mid-brain, hind-brain neurons, cortex, cerebellum and retina) with approximately 90 distinguishable color variations in cre recombined cells.
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| STOCK Tg(Thy1-Brainbow3.2)7Jrs/J (Cat. No.: CEMM-07250444) | Inquiry | |
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These Brainbow 3.2 (founder line 7) mice allow labeling of individual neuronal types (including neurons of spinal cord, cortex, hippocampus, cerebellum and retina) with approximately 90 distinguishable color variations in cre recombined cells.
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| STOCK Tg(CAG-Bgeo/GFP)21Lbe/J (Cat. No.: CEMM-07250010) | Inquiry | |
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Expression of lacZ in these mice is under the control of the CMV enhancer/chicken actin promoter and is widespread except in liver and lung tissue. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with GFP in tissues expressing cre.
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| STOCK Tg(Wnt1-cre/ERT)1Alj/J (Cat. No.: CEMM-07250136) | Inquiry | |
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These transgenic mice express a tamoxifen-inducible cre recombinase directed by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When induced, cre activity is observed in the Wnt1-expressing cells; including midbrain, developing neural tube, migrating neural crest cells and dopaminergic neuron populations.
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For Research Use Only.