Online Inquiry
STOCK Tg(Sim1-cre)1Lowl/J
Cat. No.: CEMM-07250049
When these Sim1-Cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked sequences in Sim1-expressing tissues (including hypothalamus). As such, Sim1-Cre transgenic mice may be useful in studying body weight homeostasis, obesity, leptin metabolism, or as a reporter strain for Sim1-transcription factor activity.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Sim1-cre)1Lowl
show more
close
|
| Allele Name |
transgene insertion 1
show more
close
|
| Allele Attributes |
Recombinase-expressing
show more
close
|
| Gene Symbol |
Tg(Sim1-cre)1Lowl
show more
close
|
| Gene Name |
transgene insertion 1
show more
close
|
| Chromosome |
UN
show more
close
|
| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
show more
close
|
| MGI Accession ID | show more close |
| Site of Expression |
All areas that endogenously express Sim1, including paraventricular hypothalamus and other parts of the brain
show more
close
|
| Strain of Origin |
FVB
show more
close
|
| Molecular Note |
The Cre ATG was inserted via recombineering techniques, into the Sim1 ATG site of a BAC containing 137.1 kb of genomic C57BL/6 Sim1 sequences up to and including exon 8. The inserted Cre sequence deleted the first 31 bp of the Sim1 gene.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
Noncarrier
show more
close
|
| Breeding Considerations |
When maintaining a live colony, hemizygous mice are bred to wildtype siblings.
show more
close
|
For Research Use Only.
Related Products