STOCK Tg(Wnt1-cre/ERT)1Alj/J

Cat. No.: CEMM-07250136

Common Name: Wnt1-CreERT

These transgenic mice express a tamoxifen-inducible cre recombinase directed by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When induced, cre activity is observed in the Wnt1-expressing cells; including midbrain, developing neural tube, migrating neural crest cells and dopaminergic neuron populations.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Wnt1-cre/ERT)1Alj show more close
Allele Name	transgene insertion 1 show more close
Allele Attributes	Recombinase-expressing; Inducible show more close
Gene Symbol	Tg(Wnt1-cre/ERT)1Alj show more close
Gene Name	transgene insertion 1 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	4359399 show more close
Site of Expression	Cre recombinase activity is observed throughout the mesencephalon (midbrain) and rhombomere 1 (~E8.5), or more restricted to the dorsal and ventral midline of the midbrain and a ring around the posterior border of the midbrain (E9.5-12.5), lateral edge of the neural plate (lower rhombic lip) in rhombomere2- rhombomere7, spinal cord and diencephalon, as well as progenitor populations giving rise to migrating neural crest cells and dopaminergic neuron populations (E9.5-12.5). show more close
Strain of Origin	Swiss Webster show more close
Molecular Note	cDNA encoding the Cre/ERT fusion protein was inserted into a vector containing the Wnt1 enhancer. Two lines showing similar expression patterns in reporter mice were generated. show more close

HUSBANDRY
Suggested Controls	Noncarrier show more close
Breeding Considerations	When maintaining a live colony, hemizygous mice may be bred to non-carrier (wildtype) siblings. The donating investigator has not determined the phenotype of homozygous mice to date. show more close

For Research Use Only.