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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129(SJL)-Kcng4tm1.1(cre)Jrs/J (Cat. No.: CEMM-07250728) | Inquiry | |
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The Kcng4Cre knock-in/knock-out allele was designed to both abolish endogenous gene function and allow the Kcng4 promoter/enhancer regions to direct Cre recombinase expression to type 5 ON bipolar cells (BC5s), as well as subsets of alpha retinal ganglion cells (a-RGC). These mice may be useful for recombining lox-flanked (floxed) alleles in studying photoreceptors and retinal circuitry.
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| B6.129(SJL)-Neto1tm1.1(cre)Jrs/J (Cat. No.: CEMM-07250729) | Inquiry | |
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The Neto1Cre knock-in/knock-out allele was designed to both abolish endogenous gene function and allow the Neto1 promoter/enhancer regions to direct Cre recombinase expression to type 2 OFF bipolar cells (BC2s), as well as some amacrine cells and retinal ganglion cells (RGCs). These mice may be useful for recombining lox-flanked (floxed) alleles in studying photoreceptors and retinal circuitry.
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| B6.Cg-Cdh6tm1.1(cre/ERT2)Jrs/J (Cat. No.: CEMM-07250731) | Inquiry | |
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The Cdh6CreER (Cdh6-CreER) knock-in/knock-out allele was designed to both abolish endogenous gene function and allow the Cdh6 promoter/enhancer regions to direct tamoxifen-inducible Cre recombinase expression to ON-OFF direction-selective retinal ganglion cells (ooDSGCs) that respond to vertical motion (dorsal and ventral), as well as to starburst amacrine cells. These mice may be useful for tamoxifen-inducible recombination of lox-flanked (floxed) alleles in studying photoreceptors and retinal circuitry.
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| B6;129-Ntstm1(cre)Mgmj/J (Cat. No.: CEMM-07250352) | Inquiry | |
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These mutant mice feature a nondisruptive Cre recombinase knock-in at the endogenous Neurotensin locus. They may be useful for generating conditional mutations in studies related to metabolism and energy homeostasis.
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| STOCK Stag2tm1c(EUCOMM)Wtsi/J (Cat. No.: CEMM-07250833) | Inquiry | |
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The "conditional ready" (floxed) Stag2tm1c(EUCOMM)Wtsi allele (Stag2flox) has loxP sites flanking exon 7. Exposure to Cre recombinase creates the knock-out allele. These mice may be useful in studying the cohesin complex and STAG2 loss-of-function mutations in diseases such as cancer.
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| B6.129-Htr2ctm1Jke/J (Cat. No.: CEMM-07250294) | Inquiry | |
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These mutant mice contain a loxP-flanked transcriptional blocker cassette inserted between exon 3 and 4 of the Htr2c gene. The floxed-transcriptional blocker cassette abolishes gene function. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have the floxed-transcriptional blocker cassette removed, resulting in rescued Htr2c gene function. These mice may be useful for studying serotonin induced appetite suppression in obesity and diabetes.
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| STOCK Gt(ROSA)26Sortm1(rtTA, EGFP)Nagy TgTn(pb-tetO-Pou5f1, -Klf4, -Myc, -Sox2, -mCherry)250Nagy/J (Cat. No.: CEMM-07250841) | Inquiry | |
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Cre-inducible iRep1 without Oct4-GFP mice, also called ROSA26-rtTA(neo); OKMSCh250, have the Cre-inducible ROSA26-rtTA(neo) allele and the TetO-OKMS-mCherry transgene from line 250 (OKMSCh250). Following Cre recombinase exposure, these mice allow doxycycline (dox)-inducible expression of a polycistronic OKMS cassette encoding four transcription factors (Oct4 [Pou5f1], Klf4, c-Myc [Myc] and Sox2) - which reprograms somatic cells that are derived from these animals to embryonic stem cell-like induced pluripotent stem cells (iPSCs). In addition, OKMS expression is accompanied by mCherry fluorescence.
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| STOCK Gt(ROSA)26Sortm1(rtTA, EGFP)Nagy TgTn(pb-tetO-Pou5f1, -Klf4, -Myc, -Sox2, -mCherry)250Nagy Tg(Pou5f1-EGFP)1Nagy/J (Cat. No.: CEMM-07250840) | Inquiry | |
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Cre-inducible iRep1 mice, also called Oct4-GFP; ROSA26-rtTA(neo); OKMSCh250, have the Oct4-GFP transgene, the Cre-inducible ROSA26-rtTA(neo) allele and the TetO-OKMS-mCherry transgene from line 250 (OKMSCh250). Following Cre recombinase exposure, these mice allow doxycycline (dox)-inducible expression of a polycistronic OKMS cassette encoding four transcription factors (Oct4 [Pou5f1], Klf4, c-Myc [Myc] and Sox2) - which reprograms somatic cells that are derived from these animals to embryonic stem cell-like induced pluripotent stem cells (iPSCs). In addition, OKMS expression is accompanied by mCherry fluorescence, and the Oct4-GFP transgene allows EGFP fluorescent determination of iPSC reprogramming/pluripotency status.
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| FVB-Tg(GFAP-cre)25Mes/J (Cat. No.: CEMM-07250018) | Inquiry | |
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Homozygotes for this transgene are not viable. Hemizygotes express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target, and recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants.
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| B6.129S-Grprtm2(icre)Zfc/J (Cat. No.: CEMM-07251068) | Inquiry | |
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These Grpricre knock-in mice have an IRES-icre recombinase gene inserted immediately downstream of the stop codon in the 3' UTR of the X-linked gastrin releasing peptide receptor (Grpr) gene. This strain may useful for inducing efficient icre recombinase activity in neurons of the spinal cord dorsal horn.
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For Research Use Only.