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B6.129(SJL)-Neto1tm1.1(cre)Jrs/J

Cat. No.: CEMM-07250729

Common Name: Neto1Cre
The Neto1Cre knock-in/knock-out allele was designed to both abolish endogenous gene function and allow the Neto1 promoter/enhancer regions to direct Cre recombinase expression to type 2 OFF bipolar cells (BC2s), as well as some amacrine cells and retinal ganglion cells (RGCs). These mice may be useful for recombining lox-flanked (floxed) alleles in studying photoreceptors and retinal circuitry.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Neto1tm1.1(cre)Jrs
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Allele Name
targeted mutation 1.1
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Allele Attributes
Recombinase-expressing
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Gene Symbol
Neto1
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Gene Name
neuropilin (NRP) and tolloid (TLL)-like 1
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Chromosome
18
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Expressed Genes
Cre, Cre recombinase, bacteriophage P1
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MGI Accession ID
5688860
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Site of Expression
Cre recombinase is expressed in type 2 OFF bipolar cells (BC2s), as well as in subsets of alpha retinal ganglion cells (a-RGC), numerous uncharacterized RGCs and amacrine cells
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Strain of Origin
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Molecular Note
A Cre recombinase gene with a polyadenylation sequence and an FRT flanked neomycin resistance cassette was targeted to exon 1. Flp-mediated recombination removed the selection cassette.
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HUSBANDRY
Suggested Controls
C57BL/6J
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Breeding Considerations
The donating investigator reports that homozygous and heterozygous mice are viable and fertile with no reported phenotype abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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