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B6.129S-Grprtm2(icre)Zfc/J
Cat. No.: CEMM-07251068
Common Name: GrpriCre
These Grpricre knock-in mice have an IRES-icre recombinase gene inserted immediately downstream of the stop codon in the 3' UTR of the X-linked gastrin releasing peptide receptor (Grpr) gene. This strain may useful for inducing efficient icre recombinase activity in neurons of the spinal cord dorsal horn.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Grprtm2(icre)Zfc
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Grpr
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| Gene Name |
gastrin releasing peptide receptor
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
129S7/SvEvBrd-Hprt+
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| Molecular Note |
The targeting vector was designed to insert an internal ribosome entry site (IRES) fused to a codon improved Cre recombinase (iCre), followed by a FRT flanked neomycin resistance (neo) cassette in opposite orientation, immediately downstream of the stop codon in the 3' UTR.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
The targeted gene is X-linked. When maintaining a live colony, homozygous females may be bred to hemizygous males.
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| Breeding Strategy |
Heterozygote x Hemizygote
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For Research Use Only.
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