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B6.129-Htr2ctm1Jke/J
Cat. No.: CEMM-07250294
These mutant mice contain a loxP-flanked transcriptional blocker cassette inserted between exon 3 and 4 of the Htr2c gene. The floxed-transcriptional blocker cassette abolishes gene function. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have the floxed-transcriptional blocker cassette removed, resulting in rescued Htr2c gene function. These mice may be useful for studying serotonin induced appetite suppression in obesity and diabetes.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Htr2ctm1Jke
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Null/Knockout
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| Gene Symbol |
Htr2c
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| Gene Name |
5-hydroxytryptamine (serotonin) receptor 2C
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A floxed transcription blocker cassette (loxTB) was inserted between exons 3 and 4. Expression is disrupted unless reactivated by Cre mediated recombination. The absence of transcript expression was confirmed by RT-PCR on cerebral cortex, whole hypothalamus, arcuate nucleus of the hypothalamus, and brainstem extracts.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
The flox-STOP mutation is on the X chromosome. When maintaining a live colony, homozygous females may be bred to wildtype males or to C57BL/6J inbred males. The donating investigator reports that hemizygous males have decreased survival due to seizures.
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For Research Use Only.
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