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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S-Ip6k2tm1Snyd/J (Cat. No.: CEMM-07251058) | Inquiry | |
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Ip6k2flox mice have loxP sites flanking exon 6 of the inositol hexaphosphate kinase 2 gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Ip6k2flox mice may be useful in studying cancer and cerebellar development.
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| B6;129-Cckbrtm1.1(cre)Mgmj/J (Cat. No.: CEMM-07251071) | Inquiry | |
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Cckbrcre knock-in mice have the endogenous cholecystokinin B receptor promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Cckbr-expressing cells/tissues (including neurons of the ventromedial nucleus of the hypothalamus), and may be useful in studying feeding behavior, obesity and diabetes.
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| B6.Cg-Avpr1btm2.1(cre)Wsy/J (Cat. No.: CEMM-07251078) | Inquiry | |
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Avpr1bCre knock-in/knock-out mice have the endogenous arginine vasopressin receptor 1B promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Avpr1b-expressing cells/tissues (including the caudate-putamen, olfactory bulb, and pyramidal neurons in the CA2 region of the hippocampus), and may be useful in studying memory, aggression, and regulation of the hypothalamic-pituitary-adrenal (HPA) axis.
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| C57BL/6-Gt(ROSA)26Sortm1(Fabp5)Galf/J (Cat. No.: CEMM-07251079) | Inquiry | |
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Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery.LSL-FABP5 mice have the mouse Fabp5 cDNA and a YFP reporter behind a loxP-flanked STOP cassette. These mice allow for Cre-inducible over-expression of FABP5 protein and YFP in cells/tissues as determined by the Cre promoter and may be useful in the study of immunology and infectious disease.
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| B6;129-Otx2tm1.1Tlam/J (Cat. No.: CEMM-07250990) | Inquiry | |
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Otx2flox mice have loxP sites flanking exon 2 of the orthodenticle homeobox 2 (Otx2) gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Otx2flox mice may be useful in studying neural development, retinal development, cellular proliferation, and medulloblastoma.
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| B6;SJL-Gfralem1(cre)Rsy/J (Cat. No.: CEMM-07251072) | Inquiry | |
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GfralCre mice have the endogenous GDNF family receptor alpha like (Gfral) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Gfral-expressing cells/tissues (including neurons of the area postrema and nucleus of the solitary tract) and may be useful for studying feeding behavior, obesity, and metabolism.
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| B6;SJL-Gfralem2(cre/ERT2)Rsy/J (Cat. No.: CEMM-07251073) | Inquiry | |
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GfralCreERT mice have the endogenous GDNF family receptor alpha like (Gfral) promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Gfral-expressing cells/tissues (including neurons of the area postrema and nucleus of the solitary tract) and may be useful for studying feeding behavior, obesity, and metabolism.
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| STOCK Calcrtm1.1(cre)Mgmj/J (Cat. No.: CEMM-07251085) | Inquiry | |
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CalcrCre mice have the endogenous calcitonin receptor (Calcr) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Calcr-expressing cells/tissues (including neurons of the nucleus of the solitary tract, hypothalamus, and lateral reticular nucleus) and may be useful for studying feeding behavior, obesity, and metabolism.
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| B6N.Cg-Gt(ROSA)26Sortm1(CAG-EGFP*)Thm/J (Cat. No.: CEMM-07250927) | Inquiry | |
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MitoTag (Rosa26-CAG-LSL-GFP-OMM) is a Gt(ROSA)26Sor knock-in allele that has a loxP-flanked STOP cassette preventing transcription of an outer mitochondrial membrane-targeted enhanced green fluorescent protein (GFP-OMM). These mice are designed to allow strong/robust EGFP fluorescence that faithfully localizes to mitochondria (with no observed cytosolic fluorescence) after exposure to Cre recombinase.
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| C57BL/6J-Kif1aem8Lutzy/Mmjax (Cat. No.: CEMM-07251002) | Inquiry | |
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Kif1a cKO is a CRISPR/Cas9 generated mutant of the kinesin family member 1A gene with loxP sites flanking exon 3. Exposure to Cre recombinase deletes the floxed sequence - creating a null allele. These mice may be useful in studying KIF1A-associated neurological disorder (KAND).
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For Research Use Only.