Products

Online Inquiry

B6.Cg-Avpr1btm2.1(cre)Wsy/J

Cat. No.: CEMM-07251078

Common Name: V1brCre
Avpr1bCre knock-in/knock-out mice have the endogenous arginine vasopressin receptor 1B promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Avpr1b-expressing cells/tissues (including the caudate-putamen, olfactory bulb, and pyramidal neurons in the CA2 region of the hippocampus), and may be useful in studying memory, aggression, and regulation of the hypothalamic-pituitary-adrenal (HPA) axis.
Inquiry
Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Avpr1btm2.1(cre)Wsy
show more close
Allele Name
targeted mutation 2.1
show more close
Allele Attributes
Recombinase-expressing; Null/Knockout
show more close
Gene Symbol
Avpr1b
show more close
Gene Name
arginine vasopressin receptor 1B
show more close
Chromosome
1
show more close
MGI Accession ID
6764454
show more close
Strain of Origin
(C57BL/6N x 129S6/SvEvTac)F1
show more close
Molecular Note
The Cre-nuclear localization sequence and FRT flanked pgk-neo cassette was inserted to replace the coding region from the initiating codon in exon 1 of the mouse Avpr1b gene by homologous recombination in the ES cells. The chimeras generated from correctly targetted ES cells were crossed to the FLPe deleter to remove the pgk-neo cassette. The absence of Avpr1b mRNA in brain of homozygous mice was confirmed.
show more close
HUSBANDRY
Suggested Controls
C57BL/6J
show more close
Breeding Considerations
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
show more close
Breeding Strategy
Heterozygote x Heterozygote
show more close
For Research Use Only.
Related Products