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STOCK Calcrtm1.1(cre)Mgmj/J
Cat. No.: CEMM-07251085
Common Name: Calcr-Cre
CalcrCre mice have the endogenous calcitonin receptor (Calcr) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Calcr-expressing cells/tissues (including neurons of the nucleus of the solitary tract, hypothalamus, and lateral reticular nucleus) and may be useful for studying feeding behavior, obesity, and metabolism.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Calcrtm1.1(cre)Mgmj
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Calcr
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| Gene Name |
calcitonin receptor
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting plasmid containing the porcine teschoviral 2A cleavage sequence linked to Cre recombinase and a Frt-flanked neomycin resistance gene replacing the stop codon of the Calcr gene in a bacterial artificial chromosome (RP24-193M22) was used for embryonic stem cell targeting. Chimeric animals generated were mated to Flp-deleter mice to remove the neomycin selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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