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B6;129-Otx2tm1.1Tlam/J
Cat. No.: CEMM-07250990
Common Name: Otx2flox
Otx2flox mice have loxP sites flanking exon 2 of the orthodenticle homeobox 2 (Otx2) gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Otx2flox mice may be useful in studying neural development, retinal development, cellular proliferation, and medulloblastoma.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Otx2tm1.1Tlam
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Otx2
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| Gene Name |
orthodenticle homeobox 2
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| Chromosome |
14
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| MGI Accession ID | show more close |
| Strain of Origin |
129/Sv
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| Molecular Note |
LoxP sites were inserted to flank exon 2.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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