Online Inquiry
Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Igs7tm140.1(tetO-EGFP, CAG-tTA2)Hze/J (Cat. No.: CEMM-07250788) | Inquiry | |
|
Ai140(TIT2L-GFP-ICL-tTA2)-D (also called Ai140D) mice are a Cre-dependent, Tet-controllable fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in EGFP fluorescence and tTA2 expression - and that EGFP expression may be diminished/eliminated by doxycycline.
show more
close
|
||
| STOCK Tbx18tm1Sev/J (Cat. No.: CEMM-07250872) | Inquiry | |
|
Tbx18:nlacZ/nGFP knock-in/knock-out has the endogenous T-box18 promoter/enhancer sequences directing expression of nuclear-localized lacZ before exposure to Cre recombinase. Subsequent Cre recombination results in nuclear GFP fluorescence. These mice may be useful in studying pericytes and vascular smooth muscle cells in multiple tissues, as well as proepicardium/epicardium cell lineages, cardiac fibroblasts and pacemaker cells of the sino-atrial node.
show more
close
|
||
| STOCK Tbx18tm3.1(cre/ERT2)Sev/J (Cat. No.: CEMM-07250873) | Inquiry | |
|
Tbx18-CreERT2 knock-in/knock-out has the endogenous T-box18 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice allow specific and inducible genetic manipulations in vivo for studying pericytes and vascular smooth muscle cells in multiple tissues, as well as proepicardium/epicardium cell lineages and pacemaker cells of the sino-atrial node.
show more
close
|
||
| B6;129S6-Igs7tm140(tetO-EGFP, CAG-tTA2)Hze/J (Cat. No.: CEMM-07250974) | Inquiry | |
|
Ai140 (also called Ai140(TIT2L-EGFP-ICL-tTA2)) is a Cre-dependent, Tet-controllable fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes - resulting in tTA2 expression and robust EGFP fluorescence. EGFP expression may be expected to be diminished/eliminated by doxycycline.
show more
close
|
||
| B6.Cg-Igs7tm173(tetO-EGFP/Hdac1, CAG-tdTomato, -tTA2)Tasic/J (Cat. No.: CEMM-07250975) | Inquiry | |
|
Ai173 (also called Ai173(TIT2L-EGFP-HDAC1-ICL-tdT-tTA2)) is a Cre-dependent, Tet-controllable histone deacetylation tool strain with dual fluorescent reporters, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes, resulting in tTA2 expression, robust tdTomato fluorescence and EGFP/HDAC1 fusion protein expression. HDAC1 is a potent epigenetic regulator and its overexpression will promote histone deacetylation. EGFP/HDAC1 expression may be expected to be diminished/eliminated by doxycycline.
show more
close
|
||
| B6.Cg-Igs7tm175(tetO-EGFP/RNAi:Pou5f1, CAG-tdTomato, -tTA2)Tasic/J (Cat. No.: CEMM-07250977) | Inquiry | |
|
Ai175 (also called Ai175(TIT2L-EGFP-shOct4-ICL-tdT-tTA2)) is a Cre-dependent, Tet-controllable transcription tool strain with dual fluorescent reporters, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes, resulting in tTA2 expression, robust tdTomato fluorescence and EGFP/shOct4 fusion protein expression (robust EGFP fluorescence and potential knockdown of endogenous Pou5f1 expression by short hairpin RNA shOct4). The EGFP/shOct4 expression may be expected to be diminished/eliminated by doxycycline.
show more
close
|
||
| B6;129S6-Igs7tm193(CAG-EGFP, CAG-tdTomato)Tasic/J (Cat. No.: CEMM-07250978) | Inquiry | |
|
Ai193 (also called Ai193(TICL-EGFP-ICF-tdT)) is a dual-recombinase responsive reporter allele designed with a CAG promoter, loxP-STOP-loxP and EGFP coding sequence followed by a CAG promoter, frt-STOP-frt and tdTomato coding sequence - all inserted into the Igs7 locus (TIGRE). Exposure to either Cre or FLP recombinase results in EGFP fluorescence or tdTomato fluorescence, respectively. Furthermore, Ai193 are a Cre::FLP intersectional fluorescent reporter line as they are designed to allow both EGFP and tdTomato fluorescence in those cells where Cre and FLP expression overlaps.
show more
close
|
||
| B6;129S6-Igs7tm213(CAG-EGFP, CAG-mOrange2, CAG-mKate2)Tasic/J (Cat. No.: CEMM-07250980) | Inquiry | |
|
Ai213 (also called Ai213(TICL-EGFP-ICF-mOrange2-ICN-mKate2)) is a triple-recombinase responsive reporter allele designed with a CAG promoter, loxP-STOP-loxP and EGFP coding sequence, followed by a CAG promoter, frt-STOP-frt and mOrange2 coding sequence which is followed by a CAG promoter, nox-STOP-nox and mKate2 coding sequence - all inserted into the Igs7 locus (TIGRE). Exposure to either Cre, FLP or Nigri recombinase results in EGFP fluorescence, mOrange2 fluorescence or mKate2 fluorescence, respectively. In total, Ai213 mice are a Cre::FLP::Nigri intersectional fluorescent reporter line designed to allow EGFP/mOrange2/mKate2 fluorescence in those cells where Cre, FLP and Nigri expression overlaps. Ai213 may also be useful as dual-recombinase responsive fluorescent reporter (e.g., Cre/FLP-dependent EGFP/mOrange2, Cre/Nigri-dependent EGFP/mKate2 and/or Cre/Nigri-dependent EGFP/mKate2 fluorescence), as well as a single recombinase responsive fluorescent reporter (e.g., Cre-dependent EGFP, FLP-dependent mOrange2 and/or Nigri-dependent mKate2 fluorescence).
show more
close
|
||
| B6.Cg-Igs7tm215(CAG-ACR2*, CAG-GCaMP7s)Tasic/J (Cat. No.: CEMM-07251109) | Inquiry | |
|
Ai215 (also called Ai215 (TICL-stGtACR2-HA-ICL-GCaMP7s-SS)) is a Cre-dependent optogenetic and fluorescent calcium-indicator tool allele designed with a CAG promoter, loxP-STOP-loxP and stGtACR2 coding sequence followed by a CAG promoter, lox2272-STOP-lox2272 and GCaMP7s coding sequence - all inserted into the Igs7 locus (TIGRE). Exposure to Cre recombinase results in expression of stGtACR2 (soma-targeted variant of the red-shifted, light-gated anion channelrhodopsin GtACR2; neuronal silencing) and/or GCaMP7s fluorescence.
show more
close
|
||
| B6.Cg-Igs7tm224(CAG-EGFP, CAG-dTomato)Tasic/J (Cat. No.: CEMM-07251110) | Inquiry | |
|
Ai224 (also called Ai224 (TICL-nls-EGFP-ICF-nls-dTom)) is a dual-recombinase responsive reporter allele designed with a CAG promoter, loxP-STOP-loxP and EGFP coding sequence with a nuclear localization sequence followed by a CAG promoter, frt-STOP-frt and dTomato coding sequence with a nuclear localization sequence - all inserted into the Igs7 locus (TIGRE). Exposure to either Cre or FLP recombinase results in nuclear localized EGFP fluorescence or nuclear localized dTomato fluorescence, respectively. Furthermore, Ai224 are a Cre::FLP intersectional fluorescent reporter line as they are designed to allow both nuclear localized EGFP and nuclear localized dTomato fluorescence in those cells where Cre and FLP expression overlaps.
show more
close
|
||
For Research Use Only.