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STOCK Tbx18tm3.1(cre/ERT2)Sev/J
Cat. No.: CEMM-07250873
Common Name: Tbx18-CreERT2; Tbx18CreERT2; Tbx18ERT2Cre
Tbx18-CreERT2 knock-in/knock-out has the endogenous T-box18 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice allow specific and inducible genetic manipulations in vivo for studying pericytes and vascular smooth muscle cells in multiple tissues, as well as proepicardium/epicardium cell lineages and pacemaker cells of the sino-atrial node.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tbx18tm3.1(cre/ERT2)Sev
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| Allele Name |
targeted mutation 3.1
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| Allele Attributes |
Recombinase-expressing; Inducible; Null/Knockout
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| Gene Symbol |
Tbx18
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| Gene Name |
T-box18
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| Chromosome |
9
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Specified
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| Molecular Note |
A Cre/ERT2_FRT_PGK-Neo_FRT cassette was inserted into the Tbx18 locus, 6 base pairs downstream of the endogenous ATG. The neo cassette was removed by FLP mediated recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Heterozygous mice are viable and fertile with no reported gross physical or behavioral abnormalities. Homozygous mice are TBX18 null - exhibiting shortened body length and postnatal death due to severe skeletal and respiratory failure. When maintaining a live colony, heterozygous mice may be bred to wildtype littermates.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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