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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S6-Gt(ROSA)26Sortm10(CAG-Syp/EGFP*, -tdTomato)Dym/J (Cat. No.: CEMM-07250783) | Inquiry | |
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The RC::FPSit dual-recombinase intersectional allele has a frt-flanked STOP and loxP-flanked STOP that prevent transcription of synaptophysin-EGFP fusion protein and tdTomato. Exposure to FLP and Cre recombinase results in strong EGFP expression enriched at the synapse/synaptic vesicle (axonal boutons [terminal and en passant]) of the neuron subtype(s) defined by the overlap of FLP/Cre expression.
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| STOCK Igs2tm1(ACTB-EGFP, -tdTomato)Zng/Igs2tm2(ACTB-tdTomato, -EGFP)Zng/J (Cat. No.: CEMM-07250817) | Inquiry | |
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GT11ML/TG11ML (MADM-ML-11GT/TG compound heterozygous mice harbor reciprocal mutations on homologous chromosomes ("trans-heterozygous"), and are designed for MADM (mosaic analysis with double markers). Exposure to Cre- or FLP-recombinase induces fluorescent protein expression. Compared to the single loxP approach of the original MADM designs, the multiple self-recognizing lox variant sites present in the MADM-ML system result in significantly improved recombination efficiency (4-8 fold higher) with no negative impact on G2-X segregation percentage (G2-X segregation produces the desired fluorescent homozygous mutant daughter cells). This MADM-ML system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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| C57BL/6NJ-Htr3aem1(IMPC)J/Mmjax (Cat. No.: CEMM-07250819) | Inquiry | |
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This CRISPR-generated floxed allele of exon 5 of the 5-hydroxytryptamine (serotonin) receptor 3A (Htr3a) gene was generated by the Knockout Mouse Phenotyping Program (KOMP2). Htr3a encodes a ligand-gated ion channel receptor for serotonin, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.
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| STOCK Gt(ROSA)26Sortm1(CAG-EYFP*, -mEYFP*, -tdTomato*, -mTFP1*)Ben/Gt(ROSA)26Sortm2(CAG-EYFP*, -mCherry*, -EGFP*, -mCerulean*)Ben/J (Cat. No.: CEMM-07250853) | Inquiry | |
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iMb2-Control-Mosaic::iChr2-Control-Mosaic compound heterozygous mice allow several possible Cre recombination outcomes in any single cell. Each outcome results in expression of both a membrane-bound fluorescent protein and a chromatin/nuclear-localized fluorescent protein, and each is mutually exclusive and permanent. These mice are also designed to permit further introduction of genes of interest for inducible, fluorescent and functional genetic mosaic analysis (ifgMosaic or Dual ifgMosaic).
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| B6.Cg-Igs7tm134.1(tetO-COP4*H134R/EYFP)Hze/J (Cat. No.: CEMM-07250858) | Inquiry | |
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Ai134(TITL-ChR2H134R-EYFP)-D mice (also called Ai134D or Ai134(TITL-ChR2-YFP)-D) are a Cre/Tet-dependent, optogenetic line - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of an improved channelrhodopsin2/EYFP fusion protein (ChR2(H134R)-EYFP). Subsequent illumination of ChR2(H134R)-expressing (EYFP fluorescent) cells with blue light leads to reversible photostimulation of action potential firing/neural activity in these cells.
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| B6.Cg-Igs7tm162.1(tetO-GCaMP6s, CAG-tTA2)Hze/J (Cat. No.: CEMM-07250875) | Inquiry | |
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Ai162(TIT2L-GC6s-ICL-tTA2)-D (also called Ai162D) mice are a Cre-dependent, Tet-controllable, fluorescent calcium-indicator tool strain - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes, resulting in expression of tTA2 and GCaMP6s (an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). GCaMP6s expression may then be diminished by doxycycline.
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| B6(Cg)-Pbrm1tm1a(EUCOMM)Wtsi/BrugJ (Cat. No.: CEMM-07250892) | Inquiry | |
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Pbrm1lacZ mice express a β-galactosidase gene and are null for Pbrm1, in addition, exon 4 is flanked by loxP sites in this conditional knock-out-first strain. These mice may be useful in studies of clear cell renal carcinoma and von Hippel-Lindau syndrome.
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| STOCK Kif11tm1.1Nat/J (Cat. No.: CEMM-07250932) | Inquiry | |
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Cre recombinase-mediated excision of floxed exons 5 and 6 in these Kif11 CKO mice creates a knock-out allele of the mouse Kif11 (kinesin family member 11) gene. Mutations in the human gene have been associated with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy, and mental retardation.
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| STOCK Cbln2tm1.1Sud/J (Cat. No.: CEMM-07250936) | Inquiry | |
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Cbln2flox mice carry a targeted conditional reporter of Cbln2 (cerebellin 2 precursor protein) activity. Any cell that expresses Cbln2 will also express IRES-mVenus. Following cre-mediated recombination, the IRES-mVenus is deleted and the cells will express IRES-tdTomato.
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| STOCK Cbln4tm1.1Sud/J (Cat. No.: CEMM-07250937) | Inquiry | |
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Cbln4flox mice carry a targeted conditional reporter of Cbln4 (cerebellin 4 precursor protein) activity. Any cell that expresses Cbln4 will also express IRES-mVenus. Following cre-mediated recombination, the IRES-mVenus is deleted and the cells will express IRES-tdTomato.
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For Research Use Only.