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STOCK Kif11tm1.1Nat/J
Cat. No.: CEMM-07250932
Common Name: Kif11 CKO
Cre recombinase-mediated excision of floxed exons 5 and 6 in these Kif11 CKO mice creates a knock-out allele of the mouse Kif11 (kinesin family member 11) gene. Mutations in the human gene have been associated with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy, and mental retardation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kif11tm1.1Nat
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Kif11
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| Gene Name |
kinesin family member 11
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| Chromosome |
19
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
LoxP sites were introduced to introns 4 and 6. An FRT flanked neomycin cassette adjacent to the 5' loxP site was removed by Flp recombinase-mediated recombination, leaving exons 5 and 6 flanked by loxP sites.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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