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B6(Cg)-Pbrm1tm1a(EUCOMM)Wtsi/BrugJ
Cat. No.: CEMM-07250892
Common Name: Pbrm1laZ
Pbrm1lacZ mice express a β-galactosidase gene and are null for Pbrm1, in addition, exon 4 is flanked by loxP sites in this conditional knock-out-first strain. These mice may be useful in studies of clear cell renal carcinoma and von Hippel-Lindau syndrome.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pbrm1tm1a(EUCOMM)Wtsi
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| Allele Name |
targeted mutation 1a
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Null/Knockout
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| Gene Symbol |
Pbrm1
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| Gene Name |
polybromo 1
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| Chromosome |
14
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N
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| Molecular Note |
The L1L2_gt0 cassette was inserted at position 30748980 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 30749852. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be Created by flp recombinase expression in mice carrying this allele. Subsequent Cre expression results in a knockout mouse. If Cre expression occurs without flp expression, a reporter knockout mouse will be Created.
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For Research Use Only.
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