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STOCK Mirc6tm1Mtm/Mmjax
Cat. No.: CEMM-07250277
These microRNA cluster 6 (miR-654/miR-376b) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mirc6tm1Mtm
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Null/Knockout
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| Gene Symbol |
Mir654
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| Gene Name |
microRNA 654
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| Chromosome |
12
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| Expressed Genes |
lacZ, beta-galactosidase, E. coli
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| MGI Accession ID | show more close |
| Site of Expression |
When combined with a Cre-recombinase-expressing strain, LacZ expression is observed in embryonic brain and spinal cord.
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| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
A targeting vector was designed to insert an FRT site followed by a lacZ gene, a loxP site, a neomycin cassette, an FRT site and a loxP site (FRT lacZ-loxP-Neo-FRT loxP) upstream of the microRNA cluster stem loop and one loxP site immediately downstream of the microRNA stem loop.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
While maintaining a live colony, the donating investigator crossed heterozygote to wild-type.
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For Research Use Only.
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