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B6;129-Gt(ROSA)26Sortm1(Ptbp1)Szhg/J
Cat. No.: CEMM-07250763
Common Name: Rosa26LSL-FL-Ptbp1
Rosa26LSL-FL-Ptbp1 mice contain a floxed STOP cassette followed by a FLAG-tagged polypyrimidine tract binding protein 1 (Ptbp1) cDNA and an IRES/mCherry cassette. This strain may be useful when studying neuronal pre-mRNA splicing.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(Ptbp1)Szhg
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
Ptbp1, polypyrimidine tract binding protein 1, mouse, laboratory; RFP, Red Fluorescent Protein, coral; FLAG, FLAG octapeptide
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| MGI Accession ID | show more close |
| Site of Expression |
When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will express PTBP1 and mCherry in the Cre-expressing tissues.
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| Strain of Origin |
129
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| Molecular Note |
A targeting vector was designed with a splice acceptor site followed by a loxP-flanked neomycin resistance cassette fused to a polyadenylation signal. This was followed by (from 5' to 3') an FRT site, a FLAG-tagged mouse cDNA, and an internal ribosome entry site (IRES) fused to a nuclear localization signal and an mCherry sequence, and a second FRT site.
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For Research Use Only.
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