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STOCK Hoxb8tm2.1(cre)Mrc/J
Cat. No.: CEMM-07251039
Common Name: Hoxb8-ICre; Hoxb8-IRES-Cre; C8Cre
Hoxb8-ICre knock-in mice express Cre recombinase from the mouse Hoxb8 (homeobox B8) promoter. Expression of Hoxb8 is not disrupted in this knock-in line. When used in combination with conditional reporter strains (e.g. Gt(ROSA)26Sortm1(EYFP)Cos), this strain allows you to visualize a subset of microglia for modulating anxiety.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hoxb8tm2.1(cre)Mrc
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Hoxb8
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| Gene Name |
homeobox B8
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A 3.36 kb fragment consisting of Cre recombinase preceded by an internal ribosomal entry site (IRES) and followed by an FRT neo-FRT cassette was inserted into the 3' UTR of exon 2 of Hoxb8. The neomycin cassette was subsequently removed by breeding with FLPe deleter animals.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygotes and homozygotes are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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