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B6(129S4)-Kiss1tm1.1(cre/EGFP)Rpa/J
Cat. No.: CEMM-07250945
Common Name: KissCre (v2); KissCre:GFP (v2)
Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from cryorecovery.Kiss1Cre:GFP (v2) knock-in/knock-out mice express cre recombinase fused to a GFP reporter in neurons expressing the Kiss1 (KiSS-1 metastasis-suppressor) gene.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kiss1tm1.1(cre/EGFP)Rpa
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Reporter; Null/Knockout
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| Gene Symbol |
Kiss1
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| Gene Name |
KiSS-1 metastasis-suppressor
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6
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| Molecular Note |
The targeting construct contains a Cre:GFP fusion carrying Myc 3' UTR pA, and an FRT SvNeo-FRT cassette introduced to the end of the first exon, such that the sequence between the start codon and the end of that exon are deleted. Flp-mediated recombination removed the FRT flanked neo cassette. The construct removes the nuclear localization signal from Cre, uses a non-optimal initiation codon, removes part of the N-terminal sequence of Cre, adds a 3' untranslated region from the Myc gene that promotes a short mRNA half-life, and deletes part of exon 1 that includes the signal peptide.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Heterozygotes are viable and fertile. Homozygotes are infertile.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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