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B6;129-Rims2tm1.2Schc/J
Cat. No.: CEMM-07250071
Common Name: RMF-Mouse Strain RIM2a conditional KO; UTSD#1902
When bred to Cre transgenic strains, the loxP-flanked exon 5 is deleted by Cre expression to produce a "RIM2alpha" isoform null allele. This strain may be helpful in the analysis of the function of alpha-RIMs in specific brain regions.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rims2tm1.2Schc
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Rims2
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| Gene Name |
regulating synaptic membrane exocytosis 2
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting vector was designed to flank exon 5 of the gene with loxP sites and insert an FRT flanked neomycin resistance cassette in reverse orientation in intron 4 (within the loxP sites). Mice carrying the mutation were crossed with a FLP strain on a C57BL/6 and 129 mixed background driven by an actin promoter. The neomycin cassette was excised, leaving the floxed exon.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintained as a live colony, homozygotes or heterozygotes may be bred.
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For Research Use Only.
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