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STOCK Bdnftm3Jae/J
Cat. No.: CEMM-07250016
Common Name: Bdnf2lox
When bred to a strain expressing Cre recombinase under the control of a tetracycline-responsive promoter element and expressing a tetracycline-controlled activator protein in brain tissues or neuronal cells, for example, this mutant mouse strain may be useful in studies of hippocampal-dependent learning and long-term potentiation, and epilepsy respectively.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Bdnftm3Jae
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| Allele Name |
targeted mutation 3
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Bdnf
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| Gene Name |
brain derived neurotrophic factor
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A single loxP site was inserted 5' to the only coding exon, and a loxP-flanked hygromycin resistance cassette was inserted 3' to the exon. The hygromycin selection cassette was removed in ES cells by transient Cre expression leaving a single loxP site prior to the production of chimeric mice.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
This strain originated on a mixed C;129S4 background. The Donating Investigator maintained it as as a homozygote on a mixed B6, 129S4, BALB/c background. Coat color expected from breeding: Albino.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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