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B6N.129-Mecp2tm1.1Vnar/J
Cat. No.: CEMM-07250307
Common Name: Mecp2 A140V
Mecp2*A140V mice contain the amino acid mutation A140V in exon 4 of the endogenous methyl CpG binding protein 2 gene, and loxP sites flanking exons 3-4. These mice may be useful for studying impaired neurodevelopmental maturation associated with human RTT.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mecp2tm1.1Vnar
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Humanized sequence
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| Gene Symbol |
Mecp2
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| Gene Name |
methyl CpG binding protein 2
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting construct was designed to insert a loxP site followed by a FRT flanked neomycin (neo) resistance cassette upstream of exon 3 of the methyl CpG binding protein 2 (Mecp2) gene. A second loxP site was inserted in the 3' untranslated region of exon 4. A point mutation was introduced in exon 4, resulting in a missense mutation, A140V, commonly found in humans carrying Rett Syndrome (RTT) X-linked mental retardation. Flp-mediated recombination removed the neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, heterozygous females may be bred to wildtype males from the colony or to C57BL/6NJ inbred mice. Breeding of male hemizygotes is unsuccessful.
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For Research Use Only.
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