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NOD.Cg-Tg(CAG-cre/Esr1*)5Amc/J
Cat. No.: CEMM-07251001
Common Name: NOD.CAG-Cre/Esr1; CAGCre-ERTM
When these CAGGCre-ERTM mice are bred with mice carrying a floxed target gene, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed sequences in widespread cells or tissues of the offspring, including developing embryos and cultured cells derived from transgenic mice.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(CAG-cre/Esr1*)5Amc
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| Allele Name |
transgene insertion 5
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Tg(CAG-cre/Esr1*)5Amc
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| Gene Name |
transgene insertion 5
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| Chromosome |
UN
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| Expressed Genes |
cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
Tamoxifen-inducible cre; widespread pattern of expression; Tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice
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| Strain of Origin |
(C57BL/6 x CBA)F1
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| Molecular Note |
This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where Cre can excise loxP-flanked segments from conditionally modified genes.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
NOD/ShiLtJ Noncarrier
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| Breeding Considerations |
Homozygotes are not viable. Hemizygotes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
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For Research Use Only.
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