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B6(Cg)-Tmprss9tm1.2Hzo/J
Cat. No.: CEMM-07251015
Common Name: Tmprss9 conditional knockout
Exon 2 of the mouse Tmprss9 (transmembrane protease, serine 9) gene is flanked by loxP sites in these Tmprss9 conditional knock-out mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of autism.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tmprss9tm1.2Hzo
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Tmprss9
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| Gene Name |
transmembrane protease
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6NTac
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| Molecular Note |
A gene trap cassette containing an FRT site, attB site, Puromycin resistance gene, attP site, human growth hormone poly(A) signal sequence, and FRT site was inserted between exon 1 and exon 2. In addition, exon 2 was flanked by loxP sites. The Puromycin resistance gene was removed via PhiC31-mediated recombination. The human growth hormone poly(A) signal sequence was removed via Flp-mediated recombination generating a conditional allele in which exon 2 is floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J C57BL/6NJ
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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