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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Gt(ROSA)26Sortm1(CAG-mCherry, -EYFP*)Liiz/J (Cat. No.: CEMM-07250916) | Inquiry | |
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STARS (STochastic gene Activation with Regulated Sparseness) knock-in mice express mCherry or Cre-dependent membrane bound YFP (meYFP). They are suitable for use in applications related to both CNS and PNS neural circuit mapping and sparse genetic manipulation, as well as visualization of the detailed morphology of other cell types.
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| B6;129P2-Pvalbtm1(cre)Arbr/J (Cat. No.: CEMM-07250094) | Inquiry | |
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PV-Cre knock-in mice express Cre recombinase in parvalbumin-expressing neurons (such as interneurons in the brain and proprioceptive afferent sensory neurons in the dorsal root ganglia), without disrupting endogenous Pvalb expression. These mice may be useful in studying neuronal differentiation.
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| B6.129S6(FVB)-Brs3tm1.1Rei/J (Cat. No.: CEMM-07250859) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the X-linked Brs3 gene. This strain may be useful for generating conditional mutations in applications related to the regulation of metabolism and obesity.
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| B6.Cg-Tg(Thy1-cre/ERT2, -EYFP)AGfng/J (Cat. No.: CEMM-07250066) | Inquiry | |
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These transgenic mice ("SLICK" for single-neuron labeling with inducible Cre-mediated knock-out) have a tamoxifen inducible Cre-mediated recombination system and Enhanced Yellow Fluorescent Protein driven by 2 bidirectional copies of the mouse thymus cell antigen 1 promoter. When crossed with a strain containing a loxP site flanked sequence of interest. The Donating Investigator reports that founder line A mice express the transgene in small subsets of motor neurons and dorsal root ganglion neurons.
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| B6.Cg-Adora1em1(cre)Rei/J (Cat. No.: CEMM-07251049) | Inquiry | |
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Adora1-Cre knock-in mice are designed to have the endogenous Adora1 promoter/enhancer regions directing expression of Cre recombinase to multiple cell types, and in particular, providing high expression levels in neural cells. The cre knock-in results in minimal disruption to endogenous Adora1 (adenosine A1 receptor) expression. These mice are useful for studying body temperature regulation as well as cardiovascular and nervous systems.
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| STOCK Prokr2em1(icre)Cfe/Mmjax (Cat. No.: CEMM-07250891) | Inquiry | |
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ProkR2-Cre knock-in mice are designed to have codon optimized iCre recombinase expression directed to prokineticin receptor 2-expressing cells. These mice may be used to generate conditional mutations for studying gonadotropin-releasing hormone neuronal migration, olfactory bulb development, infertility, and Kallmann syndrome.
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| B6.Cg-Tg(CAG-lacZ)32And/J (Cat. No.: CEMM-07250004) | Inquiry | |
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These cΒ–STOP–lacZ mice express a transgene containing lacZ and a loxP flanked-STOP codon preventing lacZ expression.
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| B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J (Cat. No.: CEMM-07250012) | Inquiry | |
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When bred to a strain expressing Cre recombinase, enhanced GFP replaces lacZ in tissues expressing Cre in this double reporter system. Expression is widespread and observed in embryonic and adult stages except in liver and lung tissue.
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| STOCK Prtn3tm1.2Hrlu/J (Cat. No.: CEMM-07250826) | Inquiry | |
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The Prtn3 floxed allele has loxP sites flanking exon 2 of the proteinase 3 gene. Removal of the floxed sequence creates a null allele. These mice may be useful for generating tissue-specific PR3-deletion for studying the role of this serine protease in modulating physiopathological inflammatory responses, including Caspase-3–mediated spontaneous/programmed cell death in neutrophils.
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| B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J (Cat. No.: CEMM-07250289) | Inquiry | |
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This S100b-GCE transgenic strain expresses GFP and tamoxifen inducible Cre recombinase in developing bone and dorsal root ganglia and may be useful in studies of genitourinary development.
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For Research Use Only.