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B6.Cg-Adora1em1(cre)Rei/J
Cat. No.: CEMM-07251049
Common Name: Adora1-Cre
Adora1-Cre knock-in mice are designed to have the endogenous Adora1 promoter/enhancer regions directing expression of Cre recombinase to multiple cell types, and in particular, providing high expression levels in neural cells. The cre knock-in results in minimal disruption to endogenous Adora1 (adenosine A1 receptor) expression. These mice are useful for studying body temperature regulation as well as cardiovascular and nervous systems.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Adora1em1(cre)Rei
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| Allele Name |
endonuclease-mediated mutation 1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Adora1
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| Gene Name |
adenosine A1 receptor
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x DBA)F1
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| Molecular Note |
CRISPR/Cas9 genome editing is used to insert a T2A peptide sequence and Cre recombinase at the stop codon. T2A sequence adds EGRGSLLTCGDVEENPG to the C terminus of Adora1 and a proline to the N terminus of Cre.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice may be bred by homozygote or heterozygote sibling matings.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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