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STOCK Prtn3tm1.2Hrlu/J

Cat. No.: CEMM-07250826

Common Name: Prtn3flox (or PR3flox)
The Prtn3 floxed allele has loxP sites flanking exon 2 of the proteinase 3 gene. Removal of the floxed sequence creates a null allele. These mice may be useful for generating tissue-specific PR3-deletion for studying the role of this serine protease in modulating physiopathological inflammatory responses, including Caspase-3–mediated spontaneous/programmed cell death in neutrophils.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Prtn3tm1.2Hrlu
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Allele Name
targeted mutation 1.2
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Allele Attributes
Conditional ready (e.g. floxed)
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Gene Symbol
Prtn3
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Gene Name
proteinase 3
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Chromosome
10
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MGI Accession ID
7446566
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Strain of Origin
B6.Cg-Thy1a
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Molecular Note
A loxP site was inserted upstream of exon 2 and a an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp-mediated recombination removed the neo cassette.
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HUSBANDRY
Suggested Controls
C57BL/6J C57BL/6NJ
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Breeding Considerations
When maintaining a live colony, this strain may be bred as homozygotes.
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For Research Use Only.
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