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    Mouse Models

    Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.

    For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.

    • Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
    • Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
    • Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
    • Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.

    If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.

    Our Mouse Models

    Reporter Mouse
    Floxed Mouse
    Recombinase-expressing Mouse
    Inducible Mouse
    STOCK Gt(ROSA)26Sortm1(CAG-Dmrt1, -EGFP)Zark/J (Cat. No.: CEMM-07251033) Inquiry
    CAG-Stop-Dmrt1-Gfp knock-in mice conditionally express Dmrt1 (doublesex and mab-3 related transcription factor 1) and an EGFP reporter. This strain may be useful for studying vertebrate sex determination.
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    STOCK Dmrta2tm1.1Zark/J (Cat. No.: CEMM-07251034) Inquiry
    Dmrt5fl mutant mice possess loxP sites flanking exon 2 of the Dmrta2 (doublesex and mab-3 related transcription factor like family A2 or Dmrt5) gene and may be useful in generating conditional mutations to study the regulation of cerebral cortex patterning.
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    B6;129S1-Dmrtb1tm1Zark/J (Cat. No.: CEMM-07251035) Inquiry
    Dmrt6flox mutant mice possess loxP sites flanking exon 1 of the Dmrtb1 (DMRT-like family B with proline-rich C-terminal, 1 or Dmrt6) gene and may be useful in generating conditional mutations to study spermatogenesis.
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    B6.Cg-Kcnma1tm1.1Alme/J (Cat. No.: CEMM-07251036) Inquiry
    Kcnma1fl-tdTomato conditional mutant mice possess loxP sites flanking exon 2 and a tdTomato reporter (that only expresses upon cre recombination) in the Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) gene and may be useful in generating conditional mutations to study the function of BK currents.
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    B6;129-Kcnq2tm1.1Avtz/J (Cat. No.: CEMM-07251043) Inquiry
    Kcnq2fl mutant mice possess loxP sites flanking exons 2-5 of the epilepsy-associated Kcnq2 (potassium voltage-gated channel, subfamily Q, member 2) gene and may be useful in generating conditional mutations to study the regulation of neuronal excitability.
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    STOCK Kcnq3tm1.1Avtz/J (Cat. No.: CEMM-07251044) Inquiry
    Kcnq3fl mutant mice possess loxP sites flanking exons 2-4 of the epilepsy-associated Kcnq3 (potassium voltage-gated channel, subfamily Q, member 3) gene and may be useful in generating conditional mutations to study the regulation of neuronal excitability.
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    B6.Cg-Arpc3tm1Ssod/J (Cat. No.: CEMM-07251087) Inquiry
    ArpC3f mutant mice possess loxP sites flanking exon 2 of the Arpc3 (actin related protein 2/3 complex, subunit 3) gene and may be useful in generating conditional mutations to study actin meshworks, synaptic plasticity, and neuropsychiatric disorders.
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    B6J.B6N-Aldh7a1tm1c(EUCOMM)Hmgu/BlrlJ (Cat. No.: CEMM-07251047) Inquiry
    Exon 6 of the Aldh7a1 (aldehyde dehydrogenase family 7, member A1) gene is flanked by loxP sites in this conditional mutant strain. These mice may be useful in studies of lysine metabolism and pyridoxine-dependent epilepsy (PDE).
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    STOCK Gt(ROSA)26Sortm1(rtTA, EGFP)Nagy/J (Cat. No.: CEMM-07250027) Inquiry
    After breeding with mice carrying Cre recombinase, rtTA and EGFP are expressed in the tissues that express cre in the offspring.
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    STOCK Wwtr1tm1Hmc Yap1tm1Hmc/WranJ (Cat. No.: CEMM-07250807) Inquiry
    These double floxed mutant mice possess loxP sites flanking exon 2 of both the Wwtr1 and Yap1 genes. This strain may be useful for generating conditional mutations in applications related to the Hippo signaling pathway, organogenesis, tumorigenesis, and tumor suppression.
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    For Research Use Only.