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B6.Cg-Kcnma1tm1.1Alme/J
Cat. No.: CEMM-07251036
Common Name: Kcnma1fl-tdTomato
Kcnma1fl-tdTomato conditional mutant mice possess loxP sites flanking exon 2 and a tdTomato reporter (that only expresses upon cre recombination) in the Kcnma1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) gene and may be useful in generating conditional mutations to study the function of BK currents.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kcnma1tm1.1Alme
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; No functional change
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| Gene Symbol |
Kcnma1
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| Gene Name |
potassium large conductance calcium-activated channel
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| Chromosome |
14
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6NTac x 129S6/SvEvTac)F1
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| Molecular Note |
A lox71 site was inserted upstream of exon 2 and an FRT flanked neo cassette, 2A-tdTomato gene and lox66 site in inverse orientation were inserted downstream of exon 2. Flp mediated recombination removed the neo cassette. In the absence of Cre-mediated recombination the tdTomato reporter is not expressed. Following Cre-mediated the tdTomato reporter is expressed and exon 2 is placed in inverse orientation. The Cre-mediated inversion is irreversible.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice are bred by homozygote sibling matings.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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