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B6J.B6N-Aldh7a1tm1c(EUCOMM)Hmgu/BlrlJ
Cat. No.: CEMM-07251047
Common Name: Aldh7a1 floxed
Exon 6 of the Aldh7a1 (aldehyde dehydrogenase family 7, member A1) gene is flanked by loxP sites in this conditional mutant strain. These mice may be useful in studies of lysine metabolism and pyridoxine-dependent epilepsy (PDE).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Aldh7a1tm1c(EUCOMM)Hmgu
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| Allele Name |
targeted mutation 1c
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Aldh7a1
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| Gene Name |
aldehyde dehydrogenase family 7
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| Chromosome |
18
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
The L1L2_Bact_P cassette was inserted at position 56681275 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 56682076. The critical exon 6 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene and generated an exon 6 "conditional ready" (floxed) allele.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice are bred by homozygote sibling matings. The donating investigator cautions that the mice are slow breeders.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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