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B6;129-Kcnq2tm1.1Avtz/J
Cat. No.: CEMM-07251043
Common Name: Kcnq2fl
Kcnq2fl mutant mice possess loxP sites flanking exons 2-5 of the epilepsy-associated Kcnq2 (potassium voltage-gated channel, subfamily Q, member 2) gene and may be useful in generating conditional mutations to study the regulation of neuronal excitability.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Kcnq2tm1.1Avtz
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Kcnq2
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| Gene Name |
potassium voltage-gated channel
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6J x 129/Sv)F1
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| Molecular Note |
Exons 2-5 were floxed and an FRT flanked neomycin cassette was inserted via homologous recombination. Flp mediated recombination removed the neomycin cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice are bred by homozygote sibling matings.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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