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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J (Cat. No.: CEMM-07250100) | Inquiry | |
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These R26StopFLikk2ca mice allow inducible expression of an activated form of Ikbkb (IKK2ca) and subsequent activation of the NF-kappaB transcription factor pathways.
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| B6;129-Gt(ROSA)26Sortm1Joe/J (Cat. No.: CEMM-07250113) | Inquiry | |
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Homozygous ROSA26 GNZ knock-in mice have widespread expression of a nuclear-localized green fluorescent protein/beta-galactosidase fusion protein (GFP-NLS-lacZ or GNZ) once an upstream loxP-flanked STOP sequence is removed. When bred to cre expressing mice, the resulting GNZ fusion protein expression in the offspring allows for enhanced (single cell level) visualization.
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| B6.129S1(Cg)-Gdnftm1.1Neas/J (Cat. No.: CEMM-07250285) | Inquiry | |
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These Gdnfflox mutant mice possess loxP sites flanking exon 3 of the glial cell line derived neurotrophic factor (Gdnf) gene. This strain may be useful for studying gamma motor neuron function in motor control.
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| B6.129(SJL)-Oxtrtm1.1Wsy/J (Cat. No.: CEMM-07250109) | Inquiry | |
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Mice homozygous for the Oxtrflox targeted allele harbor loxP sites flanking exons 2-3 of the oxytocin receptor (Oxtr) gene, and may be used for spatial and temporal inactivation of the oxytocin receptor in studying parturition and lactation, as well as social, behavioral, and learning disorders such as autism and anxiety.
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| C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J (Cat. No.: CEMM-07250072) | Inquiry | |
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The Cre-inducible expression of DTR in these iDTR knock-in mice render cells susceptible to ablation following Diphtheria toxin administration.
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| B6;129-Nrxn3tm4.1Sud/J (Cat. No.: CEMM-07250306) | Inquiry | |
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These NS4 mutant mice possess loxP sites flanking exon 20 (alternative splice site 4) of the neurexin III (Nrxn3) gene, and a mutated exon 20 splice acceptor sequence. This strain may be useful for studying neuronal synapses related to alcoholism, dependence, and addiction behaviors.
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| STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ (Cat. No.: CEMM-07250529) | Inquiry | |
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Ai93(TITL-GCaMP6f)-D;Rosa26-ZtTA (or Ai93D;R26-ZtTA) mice have a Cre/Tet-dependent, fluorescent calcium indicator GCaMP6f inserted into the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated), as well as a Cre-dependent tetracycline-controlled transactivator protein (tTA) inserted into the Gt(ROSA)26Sor locus on chromosome 6. After removal of the floxed-STOP cassettes by Cre recombinase, resulting mice have doxycycline-inducible/reversible expression of GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics). Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.
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| STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm94.1(tetO-GCaMP6s)Hze/J (Cat. No.: CEMM-07250532) | Inquiry | |
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Ai94(TITL-GCaMP6s)-D;Rosa26-ZtTA (or Ai94D;Rosa26-ZtTA) mice have a Cre/Tet-dependent, fluorescent calcium indicator GCaMP6s inserted into the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated), as well as a Cre-dependent tetracycline-controlled transactivator protein (tTA) inserted into the Gt(ROSA)26Sor locus on chromosome 6. After removal of the floxed-STOP cassette by Cre recombinase, resulting mice have doxycycline-inducible/reversible expression of GCaMP6 slow variant calcium indicator (GCaMP6s; an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). Following subsequent calcium binding (such as neuronal activation), increased EGFP fluorescence is observed in those cells.
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| STOCK Igs7tm93.1(tetO-GCaMP6f)Hze Tg(Camk2a-tTA)1Mmay/J (Cat. No.: CEMM-07250530) | Inquiry | |
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Ai93(TITL-GCaMP6f)-D;CaMK2a-tTA (or Ai93D;CaMK2a-tTA) mice have a Cre/Tet-dependent, fluorescent calcium indicator GCaMP6f inserted into the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated), as well as a transgene directing tetracycline-controlled transactivator protein (tTA) expression in forebrain neurons. After removal of the floxed-STOP cassette by Cre recombinase, resulting mice have doxycycline-inducible/reversible expression of GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics) in forebrain neurons. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed. As described for, the CaMK2a-tTA transgene integrated into chromosome 12 causing a 508 Kb deletion that spans the 3' half of Vipr2, the entire Wdr60, Esyt2, D430020J02Rik and Ncapg2 loci and the first two exons of Ptprn2. Homozygous mice will therefore have a functional knock-out of the deleted loci, and altered or null expression of Vipr2 and Ptprn2.
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| B6.Cg-Pabpn1tm1.1Gpvl/J (Cat. No.: CEMM-07250716) | Inquiry | |
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Pabpn1 conditional knock-in mice possess a 17-alanine (17) expanded Pabpn1 gene. Expression of this knock-in is prevented by an upstream floxed sequence containing a WT mouse Pabpn1 gene and an EGFP sequence. Cre Recombinase excision of the floxed region results in the expression of Pabpn1A17, associated with the onset of Oculopharyngeal muscular dystrophy (OPMD).
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