B6.129S1(Cg)-Gdnftm1.1Neas/J

Cat. No.: CEMM-07250285

These Gdnfflox mutant mice possess loxP sites flanking exon 3 of the glial cell line derived neurotrophic factor (Gdnf) gene. This strain may be useful for studying gamma motor neuron function in motor control.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Gdnftm1.1Neas
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Allele Name
targeted mutation 1.1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Gdnf
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Gene Name
glial cell line derived neurotrophic factor
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Chromosome
15
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Strain of Origin
129S1/Sv-Oca2+ Tyr+ Kitl+
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Molecular Note
An FRT flanked neo cassette was inserted upstream of a modified exon 3 in which the coding sequence was floxed. Flp mediated recombination removed the neo cassette leaving the coding sequence floxed.
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HUSBANDRY
Suggested Controls
C57BL/6J
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Breeding Considerations
When maintaining a live colony, homozygous mice may be bred.
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For Research Use Only.
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