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B6;129-Nrxn3tm4.1Sud/J
Cat. No.: CEMM-07250306
Common Name: NS4
These NS4 mutant mice possess loxP sites flanking exon 20 (alternative splice site 4) of the neurexin III (Nrxn3) gene, and a mutated exon 20 splice acceptor sequence. This strain may be useful for studying neuronal synapses related to alcoholism, dependence, and addiction behaviors.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nrxn3tm4.1Sud
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| Allele Name |
targeted mutation 4.1
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| Allele Attributes |
Modified isoform(s)
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| Gene Symbol |
Nrxn3
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| Gene Name |
neurexin III
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| Chromosome |
12
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting vector was designed to insert a loxP site upstream of exon 20 (alternative splice site 4) followed by a FRT flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 20. The less common splice acceptor sequence of exon 20 (TGTTTTTTAAACTTTAAAG) was substituted with a much more common one (TGTTTTTTCGTCTTCCTAG) to make the exon always incorporated in the transcript.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous or heterozygous mice may be bred together. The donating investigator reports 30% of animals don't produce offspring.
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For Research Use Only.
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