Online Inquiry
Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Gt(ROSA)26Sortm3.2(CAG-EGFP, -CHRM3*/mCherry/Htr2a)Pjen/J (Cat. No.: CEMM-07250622) | Inquiry | |
|
This strain is currently unavailable due to replenishing of cryopreserved stocks. Interested customers can register interest.RC::FL-hM3Dq is a dual recombinase-responsive Gq-coupled DREADD allele with a frt-flanked STOP and a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Flp-recombinase results in widespread, robust eGFP fluorescence, and further exposure to Cre recombinase may replace eGFP expression with somatodendritic hM3Dq/mCherry expression. The DREADD hM3Dq induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::FL-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation of an intersectional subpopulation defined by overlap of Flp and Cre recombinase expression.
show more
close
|
||
| D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ (Cat. No.: CEMM-07250612) | Inquiry | |
|
GFAP-Cre transgenic mice from founder line 73.12 have Cre recombinase expression directed by the mouse glial fibrillary acidic protein promoter. Cre expression is observed in astrocytes in the brain and spinal cord, as well as postnatal and adult GFAP-expressing neural stem cells and their progeny in the brain.
show more
close
|
||
| NOD.Cg-Ptgs2tm1Hahe H2b/PkamMmjax (Cat. No.: CEMM-07250581) | Inquiry | |
|
NOD.B10 Cox-2flox Line C mice develop age-related Sjogren's syndrome xerostomia and sialadenitis, and are phenotypically indistinguishable from NOD.B10Sn-H2b/J mice. Cox-2 function may be deleted when Cre recombinase is introduced.
show more
close
|
||
| B6;129-Gt(ROSA)26Sorem1(Tor1b)Wtd/J (Cat. No.: CEMM-07251088) | Inquiry | |
|
CRISPR/Extreme Genome Editing technology was used to develop TorsinB-OE mice which have a loxP-flanked STOP cassette and torsin family 1, member B (Tor1b) cDNA inserted into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in TorsinB overexpression in cre expressing tissues. This mutant mouse strain may be useful when studying the timing of nuclear envelope (NE) budding in neurons and its role in DYT1 dystonia pathogenesis and therapeutics.
show more
close
|
||
| FVB.129(B6)-Smn1tm1Jme/J (Cat. No.: CEMM-07250040) | Inquiry | |
|
These floxed mutant mice possess loxP sites flanking exon 7 of the Smn1 gene. This strain may be useful for generating conditional mutations in applications related to SMA or other neuromuscular degenerative diseases.
show more
close
|
||
| B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J (Cat. No.: CEMM-07250075) | Inquiry | |
|
Ai9 is a Cre reporter allele that has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. Ai9 mice express robust tdTomato fluorescence following Cre-mediated recombination. The Ai9 allele is very similar in design to the Ai14 allele - differing only in the presence (Ai9) or absence (Ai14) of an att site-flanked neo selection cassette at the 3' end of the targeted allele. Importantly, both Ai9 and Ai14 may exhibit low levels of tdTomato expression prior to exposure to Cre recombinase - but the tdTomato expression levels after Cre recombination are greater than those baseline levels. As such, it is recommended that researchers include Cre-negative controls to establish the baseline tdTomato levels in their experiments. See Detailed Description for additional details.
show more
close
|
||
| B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J (Cat. No.: CEMM-07250076) | Inquiry | |
|
Ai6 is a Cre reporter allele designed to have a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven enhanced green fluorescent protein variant (ZsGreen1) - all inserted into the Gt(ROSA)26Sor locus. Ai6 mice express robust ZsGreen1 fluorescence following Cre-mediated recombination.
show more
close
|
||
| B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J (Cat. No.: CEMM-07250077) | Inquiry | |
|
Ai14 is a Cre reporter allele designed to have a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. Ai14 mice express robust tdTomato fluorescence following Cre-mediated recombination. The Ai14 allele is very similar in design to the Ai9 allele - differing only in the absence (Ai14) or presence (Ai9) of an att site-flanked neo selection cassette at the 3' end of the targeted allele. Importantly, both Ai14 and Ai9 may exhibit low levels of tdTomato expression prior to exposure to Cre recombinase - but the tdTomato expression levels after Cre recombination are greater than those baseline levels. As such, it is recommended that researchers include Cre-negative controls to establish the baseline tdTomato levels in their experiments. See Detailed Description for additional details.
show more
close
|
||
| STOCK En1tm8.1Alj/J (Cat. No.: CEMM-07250084) | Inquiry | |
|
These En1flox mice harbor loxP-flanked homeodomain portion of exon 2 of the engrailed 1 (En1 locus. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing tissue(s). As such, these mice may be useful in generating conditional mutations for studying engrailed protein function in the embryonic mesencephalon and rhombomere 1, as well as developing cerebellum, limbs, somites, and skin.
show more
close
|
||
| STOCK Gbx2tm1.1Alj/J (Cat. No.: CEMM-07250090) | Inquiry | |
|
These Gbx2flox mice harbor loxP-flanked homeodomain portion of exon 2 of the gastrulation brain homeobox 2 (Gbx2) locus and may be useful in generating conditional mutations for studying gastrulation brain homeobox protein function in the embryonic mesencephalon and rhombomere 1, as well as developing cerebellum and thallamus.
show more
close
|
||
For Research Use Only.