Online Inquiry
B6;129-Gt(ROSA)26Sorem1(Tor1b)Wtd/J
Cat. No.: CEMM-07251088
Common Name: TorsinB-OE
CRISPR/Extreme Genome Editing technology was used to develop TorsinB-OE mice which have a loxP-flanked STOP cassette and torsin family 1, member B (Tor1b) cDNA inserted into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in TorsinB overexpression in cre expressing tissues. This mutant mouse strain may be useful when studying the timing of nuclear envelope (NE) budding in neurons and its role in DYT1 dystonia pathogenesis and therapeutics.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sorem1(Tor1b)Wtd
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| Allele Name |
endonuclease-mediated mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N
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| Molecular Note |
CRISPR/Extreme genome editing technology knocked-in the Tor1b cDNA that is preceded by a floxed stop cassette into the locus. Tor1b is expressed after Cre-mediated deletion of the stop cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together. The donating investigator reports some growth reduction.
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For Research Use Only.
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